Systematic Reviews & Meta-Analyses

  1. Bruton AM, Nauman J, Hanes D, Gard M, Senders A. Phosphatidylserine for the treatment of pediatric attention-deficit/hyperactivity disorder (ADHD): A systematic review and meta-analysis. J Altern Complement Med. 2021 Feb 4. https://doi.org/10.1089/acm.2020.0432.
  2. Sibley MH, Bruton AM, Zhao X, Johnstone JM, Mitchell JT, Hatsu I, Arnold LE, Basu HH, Levy L, Vyas P, Macphee F, Schoenfelder Gonzalez E, Kelley M, Jusko ML, Bolden CR, Zulauf-McCurdy C, Manzano M, & Torres G. Non-Pharmacological Interventions for Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Update of the Evidence. Lancet Child Adolesc Health, 2023. https://doi.org/10.1016/S2352-4642(22)00381-9.
  3. Nigg JT, Bruton AM, Kozlowski MB, Johnstone JM, Karalunas SL. Does white noise help with attention in ADHD? A systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry, 2024. https://doi.org/10.1016/j.jaac.2023.12.014
  4. Bruton AM, Wesemann DG, Machingo TA, Majak G, Johnstone JM, & Marshall RD. Ketamine for mood disorders, anxiety, and suicidality in adolescents: a systematic review. Eur Child Adolesc Psych, 2024. https://doi.org/10.1007/s00787-024-02458-y.
  5. Rucklidge J, Johnstone JM, Welsh A, Ast HK, Bruton AM. Micronutrients and their role in the treatment of pediatric mental illness: a review. J Child Psychol Psychiatry: under review.
  6. Bruton AM, Levy L, Rai NK, Colgan DD, and Johnstone JM. Diminished interoception in attention-deficit/hyperactivity disorder: a systematic review. J. Psychophysiol: in revision.
  7. Machingo TM, Bruton AM, Ryan JJ, and Johnstone JM. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and ADHD: a scoping review. Adv Neurodevel Disorders: under review.
  8. Bruton AM, Ast HK, Colgan DD, O’Brien J, Zwickey H, Wilson AC, Price C. The association between alexithymia, interoception and pain in pediatric chronic pain: a systematic review. J Pain: under review.

Other Scientific Publications

  1. Robinette LM, Johnstone JM, Srikanth P, Bruton AM, Ralle M, AST HK, Bradley R, Leung BMY, LE Arnold, IE Hatsu. Evaluating mineral biomarkers as mediators and moderators of behavioural improvements in a randomized controlled trial of multinutrients for children with ADHD. Brit J Nutrition: in press.
  2. Tost G, Srikanth P, Bruton AM, Hatsu I, Leung B, Ast H, Eiterman L, Robinette LM, Williams C, Gracious B, Arnold LE, Johnstone JM. Personalizing outcomes by Parent Target Problem in an RCT: Which problems respond to broad-spectrum micronutrients? Eur Child Adolsc Psych: https://doi.org/10.1007/s00787-024-02463-1.
  3. Leung BMY, Srikanth P, Bruton AM, Robinette LM, Tost G, Hatsu IE, Arnold LE, Johnstone JM. Micronutrients for ADHD in Youth (MADDY) Study: Comparisons of results from RCT and Open Label Extension. Eur Child Adolesc Psychiatry, 2023. https://doi.org/10.1007/s00787-023-02236-2.
  4. Johnstone JM, Srikanth P, Robinette LM, Bruton AM, Leung BMY, Gracious BL, Hatsu IE, Vitiello B, Arnold LE. Dr. Johnstone et al. Reply to Dr. Hamilton: Ways to Examine Blinding in Randomized Clinical Trial of Micronutrients in Children with ADHD. J Am Acad Child Adolesc Psychiatry, 2023. http://doi.org/10.1016/j.jaac.2023.07.992.
  5. Johnstone JM, Arnold LE, Villagomez A, Robinette LM, Gracious BL, Ast HK, Bruton AM, Hatsu IE. Dr. Johnstone et al. Reply to Dr. Elmrayed: Dosages of Nutrient Supplements and Potential Long-Term Toxicity in ADHD Micronutrient Study. J Am Acad Child Adolesc Psychiatry, 2023. https://doi.org/10.1016/j.jaac.2023.07.994.
  6. Robinette LM, Hatsu IE, Johnstone JM, Bruton AM, Leung BMY, Arnold LE.Response to Treatment with a Multinutrient for ADHD is Independent of Diet Quality: The MADDY RCT. Nutr Neurosci, 2023. http://doi.org/10.1080/1028415X.2023.2191415.
  7. Hatsu, IE; Robinette, LM; Johnstone, JM; Bruton, AM; Leung, BMY; Orchard, T & Arnold, LE. Letter to the editor response, Nutr Neurosci, 2023. https://doi.org/10.1080/1028415X.2023.2177579
  8. Bruton AM, Senders A, Tost G, Ast H, Robinette L, Leung B, Hatsu I, Arnold LE, and Johnstone JM. Pain sensitivity and perceptual sensitivity are associated with severity of emotional dysregulation in children with ADHD: A cross-sectional analysis using the Temperament in Middle Childhood Questionnaire. Disabil Rehabil, 2022. https://doi.org/10.1080/09638288.2022.2043946.
  9. Lu S; Bruton AM; Millington E; Alexander E; Camden K; Johnstone JM; Hatsu I; Arnold LE; Leung BMY. Parents’ Priorities and Preferences for Treatment of their Children with ADHD: Qualitative Inquiry in the MADDY Study, a Multinutrient Intervention Trial. Child: Care Health Dev, 2022. https://doi/org/10.1111/cch.12995.
  10. Robinette, LM; Hatsu, I; Johnstone JM; Tost, G; Bruton, AM; Eiterman, LP; Leung, BMY; Odie, JB; Orchard, T; Gracious, BL; Arnold, LE. Fruit and Vegetable Intake is Inversely Associated with Severity of Inattention in a Pediatric Population with ADHD Symptoms: The MADDY Study. Nutr Neurosci, 2022. https://doi.org/10.1080/1028415X.2022.2071805
  11. Johnstone JM, Hatsu I, Tost G, Srikanth P, Eiterman LP, Bruton AM, Ast HK, Robinette LM, Stern MM, Millington EG, Gracious BL, Hughes AJ, Leung BMY, Arnold LE. Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial. J Am Acad Child Adolesc Psychiatry, 2021. https://doi.org/10.1016/j.jaac.2021.07.005.
  12. Johnstone JM, Leung B, Gracious B, Perez L, Tost G, Savoy A, Hatsu I, Hughes A, Bruton AM, Arnold LE. Rationale and design of an international randomized placebo-controlled trial of a 36-ingredient micronutrient supplement for children with ADHD and irritable mood: The Micronutrients for ADHD in Youth (MADDY) study. Contemp Clin Trials Commun, 2019. https://doi.org/10.1016/j.conctc.2019.100478.
  13. Bruton AM, Fuller L. Course of Concomitant Bell’s Palsy and Trigeminal Neuralgia Shortened with a Multi-Modal Intervention: A Case Report. Explore (NY), 2019. https://doi.org/10.1016/j.explore.2019.04.003
  14. Bruton AM, Fuller L. Paroxysmal Kinesigenic Dyskinesia Symptoms Markedly Reduced with Parenteral Vitamins and Minerals: A Case Report. Perm J. 2019. https://doi.org/10.7812/TPP/19.036.

Works in Progress

  1. Bruton AM, Robinette LM, Hatsu IE, Ast HK, Leung BMY. Arnold LE. Zava D. Johnstone JM. Urinary histamine not associated with severity of ADHD and emotional dysregulation symptoms: A cross-sectional secondary data analysis from the MADDY study. Adv Neurodevel Disorders: under review.
  2. Loftis J, Ast H, Srikanth P, Ramesh R, Bruton AM, Machingo TM, Hatsu IE, Robinette LM, Arnold LE, Erikson D, Johnstone JM. Multinutrient supplementation and associations with cytokines: the MADDY study. Psych Research: under review.